Pyrrolo[2,1-b]quinazolin-3-ol, 1,2,3,9-tetrahydro-
Peganine
CAS: 6159-56-4
Molecular Formula: C11H12N2O
Pyrrolo[2,1-b]quinazolin-3-ol, 1,2,3,9-tetrahydro- - Names and Identifiers
| Name | Peganine |
| Synonyms | Peganine l-peganine Vasicine (20 mg) Pyrrolo[2,1-b]quinazolin-3-ol, 1,2,3,9-tetrahydro- |
| CAS | 6159-56-4 |
Pyrrolo[2,1-b]quinazolin-3-ol, 1,2,3,9-tetrahydro- - Physico-chemical Properties
| Molecular Formula | C11H12N2O |
| Molar Mass | 188.23 |
| Density | 1.37±0.1 g/cm3(Predicted) |
| Melting Point | 211 °C |
| Boling Point | 373.8±52.0 °C(Predicted) |
| pKa | 13.08±0.20(Predicted) |
| In vitro study | Vasicine (Peganine) exhibits strongantioxidant activityin theDPPHinhibition assay with an IC 50 value of 71.97±3.79μg/mL. |
Pyrrolo[2,1-b]quinazolin-3-ol, 1,2,3,9-tetrahydro- - Risk and Safety
| HS Code | 2939800000 |
Pyrrolo[2,1-b]quinazolin-3-ol, 1,2,3,9-tetrahydro- - References
| Use | 1,2,3, 9-tetrahydropyrrolo [2,1-B] quinazolin-3-ol is a quinazoline alkaloid isolated from nature; It can be used for the preparation of linked tricarbonyl compounds and cyano analogs, as electrophilic participants in the formation of drug discovery pharmacophore templates. |
| biological activity | (±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine), isolated from Peganum harmala seeds, significantly inhibited H -K -ATPase activity with an IC50 of 73.47 μg/mL. Anti-ulcer activity. Vasicine also shows significant antisecretory, antioxidant and cytoprotective effects. |
Last Update：2024-04-09 15:17:19
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